The Perio Tray® was cleared by the FDA in 2004 as a prescription medical device to place solutions of the clinician's choice into periodontal pockets. The frequency and duration of use is determined by the practicing dentist based on individual patient needs.

In addition to data submitted to the FDA for clearance, independent analysis at the USC Center for Biofilms demonstrates efficacy of medicament placement into periodontal pockets via the Perio Tray®. An image from a scanning electron microscope shows that a tetracycline placed into a 6mm pocket via a Perio Tray® remained at sufficient concentration to form crystals on the bottom of a carrier in this 6mm pocket.